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The Interaction between Checkpoint Kinase 1 (Chk1) and the Minichromosome Maintenance (MCM) Complex Is Required for DNA Damage-induced Chk1 Phosphorylation

Chk1 is an essential mediator of the DNA damage response and cell cycle checkpoint. However, how exactly Chk1 transduces the checkpoint signaling is not fully understood. Here we report the identification of the heterohexamic minichromosome maintenance (MCM) complex that interacts with Chk1 by mass...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Han, Xiangzi, Aslanian, Aaron, Fu, Kang, Tsuji, Toshiya, Zhang, Youwei
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148893/
https://ncbi.nlm.nih.gov/pubmed/25049228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.575035
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