The Interaction between Checkpoint Kinase 1 (Chk1) and the Minichromosome Maintenance (MCM) Complex Is Required for DNA Damage-induced Chk1 Phosphorylation

Chk1 is an essential mediator of the DNA damage response and cell cycle checkpoint. However, how exactly Chk1 transduces the checkpoint signaling is not fully understood. Here we report the identification of the heterohexamic minichromosome maintenance (MCM) complex that interacts with Chk1 by mass...

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Bibliografiske detaljer
Main Authors: Han, Xiangzi, Aslanian, Aaron, Fu, Kang, Tsuji, Toshiya, Zhang, Youwei
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
DNA and Chromosomes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148893/
https://ncbi.nlm.nih.gov/pubmed/25049228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.575035
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