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Auto-regulatory Mechanisms of Phosphorylation of Checkpoint Kinase 1 (Chk1)

Chk1, a serine/threonine protein kinase, is centrally involved in cell cycle checkpoints and cellular response to DNA damage. Phosphorylation of Chk1 at two Ser/Gln (SQ) sites, Ser-317 and Ser-345, by the upstream kinase ATR is critical for checkpoint activation. However, the precise molecular mecha...

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Detalhes bibliográficos
Main Authors: Wang, Jingna, Han, Xiangzi, Zhang, Youwei
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412312/
https://ncbi.nlm.nih.gov/pubmed/22855742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-0523
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