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Auto-regulatory Mechanisms of Phosphorylation of Checkpoint Kinase 1 (Chk1)
Chk1, a serine/threonine protein kinase, is centrally involved in cell cycle checkpoints and cellular response to DNA damage. Phosphorylation of Chk1 at two Ser/Gln (SQ) sites, Ser-317 and Ser-345, by the upstream kinase ATR is critical for checkpoint activation. However, the precise molecular mecha...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3412312/ https://ncbi.nlm.nih.gov/pubmed/22855742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-0523 |
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