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Coupling Cellular Localization and Function of Checkpoint Kinase 1 (Chk1) in Checkpoints and Cell Viability

Chk1 plays a key role in regulating the replication checkpoint and DNA damage response. Recent evidence suggests that mammalian Chk1 regulates both the nuclear and cytoplasmic checkpoint events. However, mechanisms regulating cellular mobilization of Chk1 were not well understood. Here, we report th...

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Bibliografiske detaljer
Main Authors: Wang, Jingna, Han, Xiangzi, Feng, Xiujing, Wang, Zhenghe, Zhang, Youwei
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408180/
https://ncbi.nlm.nih.gov/pubmed/22692200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.350397
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