Integration of G Protein α (Gα) Signaling by the Regulator of G Protein Signaling 14 (RGS14)

RGS14 contains distinct binding sites for both active (GTP-bound) and inactive (GDP-bound) forms of Gα subunits. The N-terminal regulator of G protein signaling (RGS) domain binds active Gα(i/o)-GTP, whereas the C-terminal G protein regulatory (GPR) motif binds inactive Gα(i1/3)-GDP. The molecular b...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Brown, Nicole E., Goswami, Devrishi, Branch, Mary Rose, Ramineni, Suneela, Ortlund, Eric A., Griffin, Patrick R., Hepler, John R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423691/
https://ncbi.nlm.nih.gov/pubmed/25666614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.634329
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