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14-3-3γ binds regulator of G protein signaling 14 (RGS14) at distinct sites to inhibit the RGS14:Gα(i)–AlF(4)(−) signaling complex and RGS14 nuclear localization
Regulator of G protein signaling 14 (RGS14) is a multifunctional brain scaffolding protein that integrates G protein and Ras/ERK signaling pathways. It is also a nucleocytoplasmic shuttling protein. RGS14 binds active Gα(i/o) via its RGS domain, Raf and active H-Ras–GTP via its R1 Ras-binding domain...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6153293/ https://ncbi.nlm.nih.gov/pubmed/30093406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002816 |
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