14-3-3γ binds regulator of G protein signaling 14 (RGS14) at distinct sites to inhibit the RGS14:Gα(i)–AlF(4)(−) signaling complex and RGS14 nuclear localization

Regulator of G protein signaling 14 (RGS14) is a multifunctional brain scaffolding protein that integrates G protein and Ras/ERK signaling pathways. It is also a nucleocytoplasmic shuttling protein. RGS14 binds active Gα(i/o) via its RGS domain, Raf and active H-Ras–GTP via its R1 Ras-binding domain...

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Gerber, Kyle J., Squires, Katherine E., Hepler, John R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2018
Aiheet:
Signal Transduction
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153293/
https://ncbi.nlm.nih.gov/pubmed/30093406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002816
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