Assembly and Function of the Regulator of G protein Signaling 14 (RGS14)·H-Ras Signaling Complex in Live Cells Are Regulated by Gα(i1) and Gα(i)-linked G Protein-coupled Receptors

Regulator of G protein signaling 14 (RGS14) is a multifunctional scaffolding protein that integrates heterotrimeric G protein and H-Ras signaling pathways. RGS14 possesses an RGS domain that binds active Gα(i/o)-GTP subunits to promote GTP hydrolysis and a G protein regulatory (GPR) motif that selec...

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Bibliographische Detailangaben
Hauptverfasser: Vellano, Christopher P., Brown, Nicole E., Blumer, Joe B., Hepler, John R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561580/
https://ncbi.nlm.nih.gov/pubmed/23250758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.440057
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