Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2

We report the crystal structure of a 40mer mirror-image RNA oligonucleotide completely built from nucleotides of the non-natural L-chirality in complex with the pro-inflammatory chemokine L-CLL2 (monocyte chemoattractant protein-1), a natural protein composed of regular L-amino acids. The L-oligonuc...

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Vydáno v:Nat Commun
Hlavní autoři: Oberthür, Dominik, Achenbach, John, Gabdulkhakov, Azat, Buchner, Klaus, Maasch, Christian, Falke, Sven, Rehders, Dirk, Klussmann, Sven, Betzel, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423205/
https://ncbi.nlm.nih.gov/pubmed/25901662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7923
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