A Novel C5a-neutralizing Mirror-image (l-)Aptamer Prevents Organ Failure and Improves Survival in Experimental Sepsis

Complement factor C5a is a potent proinflammatory mediator that contributes to the pathogenesis of numerous inflammatory diseases. Here, we describe the discovery of NOX-D20, a PEGylated biostable mirror-image mixed (l-)RNA/DNA aptamer (Spiegelmer) that binds to mouse and human C5a with picomolar af...

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Bibliografiske detaljer
Main Authors: Hoehlig, Kai, Maasch, Christian, Shushakova, Nelli, Buchner, Klaus, Huber-Lang, Markus, Purschke, Werner G, Vater, Axel, Klussmann, Sven
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863792/
https://ncbi.nlm.nih.gov/pubmed/23887360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.178
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