Tumor clone dynamics in lethal prostate cancer

It is unclear whether a single clone metastasizes and remains dominant over the course of lethal prostate cancer. We describe the clonal architectural heterogeneity at different stages of disease progression by sequencing serial plasma and tumor samples from 16 ERG-positive patients. By characterizi...

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Udgivet i:Sci Transl Med
Main Authors: Carreira, Suzanne, Romanel, Alessandro, Goodall, Jane, Grist, Emily, Ferraldeschi, Roberta, Miranda, Susana, Prandi, Davide, Lorente, David, Frenel, Jean-Sebastien, Pezaro, Carmel, Omlin, Aurelius, Rodrigues, Daniel Nava, Flohr, Penelope, Tunariu, Nina, de Bono, Johann S., Demichelis, Francesca, Attard, Gerhardt
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422178/
https://ncbi.nlm.nih.gov/pubmed/25232177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3009448
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