Structural mechanisms of DREAM complex assembly and regulation

The DREAM complex represses cell cycle genes during quiescence through scaffolding MuvB proteins with E2F4/5 and the Rb tumor suppressor paralog p107 or p130. Upon cell cycle entry, MuvB dissociates from p107/p130 and recruits B-Myb and FoxM1 for up-regulating mitotic gene expression. To understand...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Guiley, Keelan Z., Liban, Tyler J., Felthousen, Jessica G., Ramanan, Parameshwaran, Litovchick, Larisa, Rubin, Seth M.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421984/
https://ncbi.nlm.nih.gov/pubmed/25917549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.257568.114
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