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Selective targeting of the α5-subunit of GABA(A) receptors relaxes airway smooth muscle and inhibits cellular calcium handling
The clinical need for novel bronchodilators for the treatment of bronchoconstrictive diseases remains a major medical issue. Modulation of airway smooth muscle (ASM) chloride via GABA(A) receptor activation to achieve relaxation of precontracted ASM represents a potentially beneficial therapeutic op...
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| Publicado no: | Am J Physiol Lung Cell Mol Physiol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4421780/ https://ncbi.nlm.nih.gov/pubmed/25659897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00107.2014 |
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