Plasma pharmacokinetics of the indenoisoquinoline topoisomerase I inhibitor, NSC 743400, in rats and dogs

PURPOSE: NSC 743400 is a novel synthetic indenoisoquinoline analog under development as an anticancer agent. It is a potent topoisomerase I inhibitor with potential therapeutic advantages over FDA-approved camptothecin derivatives. In preparation for clinical development of NSC 743400, we determined...

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Publicado en:Cancer Chemother Pharmacol
Main Authors: Muzzio, Miguel, Hu, Shu-Chieh, Holleran, Julianne L., Parise, Robert A., Eiseman, Julie L., Yellow-Duke, Archibong E., Covey, Joseph M., Glaze, Elizabeth R., Engelke, Kory, Egorin, Merrill J., McCormicka, David L., Beumer, Jan H.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420695/
https://ncbi.nlm.nih.gov/pubmed/25776905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2722-y
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