Preclinical examination of clofarabine in pediatric ependymoma: Intratumoral concentrations insufficient to warrant further study

Clofarabine, a deoxyadenosine analog, was an active anticancer drug in our in vitro high-throughput screening against mouse ependymoma neurospheres. To characterize the clofarabine disposition in mice for further preclinical efficacy studies, we evaluated the plasma and central nervous system (CNS)...

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Bibliografiske detaljer
Udgivet i:Cancer Chemother Pharmacol
Main Authors: Patel, Yogesh T., Jacus, Megan O., Boulos, Nidal, Dapper, Jason D., Davis, Abigail D., Vuppala, Pradeep K., Freeman, Burgess B., Mohankumar, Kumarasamypet M., Throm, Stacy L., Gilbertson, Richard J., Stewart, Clinton F.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420645/
https://ncbi.nlm.nih.gov/pubmed/25724157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2713-z
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