Simvastatin Hydroxy Acid Fails to Attain Sufficient Central Nervous System Tumor Exposure to Achieve a Cytotoxic Effect: Results of a Preclinical Cerebral Microdialysis Study

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors were potent hits against a mouse ependymoma cell line, but their effectiveness against central nervous system tumors will depend on their ability to cross the blood–brain barrier and attain a sufficient exposure at the tumor. Among 3-hydroxy...

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Sparad:
Bibliografiska uppgifter
I publikationen:Drug Metab Dispos
Huvudupphovsmän: Patel, Yogesh T., Jacus, Megan O., Davis, Abigail D., Boulos, Nidal, Turner, David C., Vuppala, Pradeep K., Freeman, Burgess B., Gilbertson, Richard J., Stewart, Clinton F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2016
Ämnen:
Short Communication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810761/
https://ncbi.nlm.nih.gov/pubmed/26802130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.068445
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