AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei—Crystal structure, mode of action, and biological activity

Melioidosis is a tropical bacterial infection caused by Burkholderia pseudomallei (B. pseudomallei; Bpm), a Gram-negative bacterium. Current therapeutic options are largely limited to trimethoprim-sulfamethoxazole and β-lactam drugs, and the treatment duration is about 4 months. Moreover, resistance...

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Bibliografski detalji
Izdano u:Protein Sci
Glavni autori: Narasimha Rao, Krishnamurthy, Lakshminarasimhan, Anirudha, Joseph, Sarah, Lekshmi, Swathi U, Lau, Ming-Seong, Takhi, Mohammed, Sreenivas, Kandepu, Nathan, Sheila, Yusof, Rohana, Abd Rahman, Noorsaadah, Ramachandra, Murali, Antony, Thomas, Subramanya, Hosahalli
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2015
Teme:
Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420531/
https://ncbi.nlm.nih.gov/pubmed/25644789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2655
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