Flow-induced protein kinase A–CREB pathway acts via BMP signaling to promote HSC emergence

Fluid shear stress promotes the emergence of hematopoietic stem cells (HSCs) in the aorta–gonad–mesonephros (AGM) of the developing mouse embryo. We determined that the AGM is enriched for expression of targets of protein kinase A (PKA)–cAMP response element-binding protein (CREB), a pathway activat...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Kim, Peter Geon, Nakano, Haruko, Das, Partha P., Chen, Michael J., Rowe, R. Grant, Chou, Stephanie S., Ross, Samantha J., Sakamoto, Kathleen M., Zon, Leonard I., Schlaeger, Thorsten M., Orkin, Stuart H., Nakano, Atsushi, Daley, George Q.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419355/
https://ncbi.nlm.nih.gov/pubmed/25870201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141514
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