Flow-induced protein kinase A–CREB pathway acts via BMP signaling to promote HSC emergence

Fluid shear stress promotes the emergence of hematopoietic stem cells (HSCs) in the aorta–gonad–mesonephros (AGM) of the developing mouse embryo. We determined that the AGM is enriched for expression of targets of protein kinase A (PKA)–cAMP response element-binding protein (CREB), a pathway activat...

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Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Kim, Peter Geon, Nakano, Haruko, Das, Partha P., Chen, Michael J., Rowe, R. Grant, Chou, Stephanie S., Ross, Samantha J., Sakamoto, Kathleen M., Zon, Leonard I., Schlaeger, Thorsten M., Orkin, Stuart H., Nakano, Atsushi, Daley, George Q.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419355/
https://ncbi.nlm.nih.gov/pubmed/25870201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141514
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