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Flow-induced protein kinase A–CREB pathway acts via BMP signaling to promote HSC emergence
Fluid shear stress promotes the emergence of hematopoietic stem cells (HSCs) in the aorta–gonad–mesonephros (AGM) of the developing mouse embryo. We determined that the AGM is enriched for expression of targets of protein kinase A (PKA)–cAMP response element-binding protein (CREB), a pathway activat...
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| Pubblicato in: | J Exp Med |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4419355/ https://ncbi.nlm.nih.gov/pubmed/25870201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141514 |
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