IP(3) 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice

Tight regulation of hematopoietic stem cell (HSC) homeostasis ensures lifelong hematopoiesis and prevents blood cancers. The mechanisms balancing HSC quiescence with expansion and differentiation into hematopoietic progenitors are incompletely understood. Here, we identify Inositol-trisphosphate 3-k...

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Publicat a:Blood
Autors principals: Siegemund, Sabine, Rigaud, Stephanie, Conche, Claire, Broaten, Blake, Schaffer, Lana, Westernberg, Luise, Head, Steven Robert, Sauer, Karsten
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2015
Matèries:
Hematopoiesis and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416530/
https://ncbi.nlm.nih.gov/pubmed/25788703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-583187
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