Sptlc1 is essential for myeloid differentiation and hematopoietic homeostasis

Serine palmitoyltransferase (SPT) long-chain base subunit 1 (SPTLC1) is 1 of the 2 main catalytic subunits of the SPT complex, which catalyzes the first and rate-limiting step of sphingolipid biosynthesis. Here, we show that Sptlc1 deletion in adult bone marrow (BM) cells results in defective myeloi...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Parthibane, Velayoudame, Acharya, Diwash, Srideshikan, Sargur Madabushi, Lin, Jing, Myerscough, Dru G., Abimannan, Thiruvaimozhi, Vijaykrishna, Nagampalli, Blankenberg, Daniel, Bondada, Lavanya, Klarmann, Kimberly D., Fox, Stephen D., Andresson, Thorkell, Tessarollo, Lino, Acharya, Usha, Keller, Jonathan R., Acharya, Jairaj K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880889/
https://ncbi.nlm.nih.gov/pubmed/31751474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000729
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