Ceramide Transfer Protein Deficiency Compromises Organelle Function and Leads to Senescence in Primary Cells

Ceramide transfer protein (CERT) transfers ceramide from the endoplasmic reticulum (ER) to the Golgi complex. Its deficiency in mouse leads to embryonic death at E11.5. CERT deficient embryos die from cardiac failure due to defective organogenesis, but not due to ceramide induced apoptotic or necrot...

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Autors principals: Rao, Raghavendra Pralhada, Scheffer, Luana, Srideshikan, Sargur M., Parthibane, Velayoudame, Kosakowska-Cholody, Teresa, Masood, M. Athar, Nagashima, Kunio, Gudla, Prabhakar, Lockett, Stephen, Acharya, Usha, Acharya, Jairaj K.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958450/
https://ncbi.nlm.nih.gov/pubmed/24642596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092142
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