Ceramide Transfer Protein Deficiency Compromises Organelle Function and Leads to Senescence in Primary Cells

Ceramide transfer protein (CERT) transfers ceramide from the endoplasmic reticulum (ER) to the Golgi complex. Its deficiency in mouse leads to embryonic death at E11.5. CERT deficient embryos die from cardiac failure due to defective organogenesis, but not due to ceramide induced apoptotic or necrot...

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Detalhes bibliográficos
Main Authors: Rao, Raghavendra Pralhada, Scheffer, Luana, Srideshikan, Sargur M., Parthibane, Velayoudame, Kosakowska-Cholody, Teresa, Masood, M. Athar, Nagashima, Kunio, Gudla, Prabhakar, Lockett, Stephen, Acharya, Usha, Acharya, Jairaj K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958450/
https://ncbi.nlm.nih.gov/pubmed/24642596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092142
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