Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

Ceramide transfer protein (CERT) functions in the transfer of ceramide from the endoplasmic reticulum (ER) to the Golgi. In this study, we show that CERT is an essential gene for mouse development and embryonic survival and, quite strikingly, is critical for mitochondrial integrity. CERT mutant embr...

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Hlavní autoři: Wang, Xin, Rao, Raghavendra Pralhada, Kosakowska-Cholody, Teresa, Masood, M. Athar, Southon, Eileen, Zhang, Helin, Berthet, Cyril, Nagashim, Kunio, Veenstra, Timothy K., Tessarollo, Lino, Acharya, Usha, Acharya, Jairaj K.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2009
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615084/
https://ncbi.nlm.nih.gov/pubmed/19139267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200807176
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