Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

Ceramide transfer protein (CERT) functions in the transfer of ceramide from the endoplasmic reticulum (ER) to the Golgi. In this study, we show that CERT is an essential gene for mouse development and embryonic survival and, quite strikingly, is critical for mitochondrial integrity. CERT mutant embr...

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Detalhes bibliográficos
Main Authors: Wang, Xin, Rao, Raghavendra Pralhada, Kosakowska-Cholody, Teresa, Masood, M. Athar, Southon, Eileen, Zhang, Helin, Berthet, Cyril, Nagashim, Kunio, Veenstra, Timothy K., Tessarollo, Lino, Acharya, Usha, Acharya, Jairaj K.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615084/
https://ncbi.nlm.nih.gov/pubmed/19139267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200807176
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