IP(3) 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice

Tight regulation of hematopoietic stem cell (HSC) homeostasis ensures lifelong hematopoiesis and prevents blood cancers. The mechanisms balancing HSC quiescence with expansion and differentiation into hematopoietic progenitors are incompletely understood. Here, we identify Inositol-trisphosphate 3-k...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Siegemund, Sabine, Rigaud, Stephanie, Conche, Claire, Broaten, Blake, Schaffer, Lana, Westernberg, Luise, Head, Steven Robert, Sauer, Karsten
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416530/
https://ncbi.nlm.nih.gov/pubmed/25788703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-583187
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