IP(3) 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice

Tight regulation of hematopoietic stem cell (HSC) homeostasis ensures lifelong hematopoiesis and prevents blood cancers. The mechanisms balancing HSC quiescence with expansion and differentiation into hematopoietic progenitors are incompletely understood. Here, we identify Inositol-trisphosphate 3-k...

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Vydáno v:Blood
Hlavní autoři: Siegemund, Sabine, Rigaud, Stephanie, Conche, Claire, Broaten, Blake, Schaffer, Lana, Westernberg, Luise, Head, Steven Robert, Sauer, Karsten
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2015
Témata:
Hematopoiesis and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416530/
https://ncbi.nlm.nih.gov/pubmed/25788703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-583187
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