IP(3) 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice

Tight regulation of hematopoietic stem cell (HSC) homeostasis ensures lifelong hematopoiesis and prevents blood cancers. The mechanisms balancing HSC quiescence with expansion and differentiation into hematopoietic progenitors are incompletely understood. Here, we identify Inositol-trisphosphate 3-k...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Siegemund, Sabine, Rigaud, Stephanie, Conche, Claire, Broaten, Blake, Schaffer, Lana, Westernberg, Luise, Head, Steven Robert, Sauer, Karsten
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2015
Soggetti:
Hematopoiesis and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416530/
https://ncbi.nlm.nih.gov/pubmed/25788703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-583187
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