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Sequencing small genomic targets with high efficiency and extreme accuracy
The detection of minority variants in mixed samples demands methods for enrichment and accurate sequencing of small genomic intervals. We describe an efficient approach based on sequential rounds of hybridization with biotinylated oligonucleotides, enabling more than one-million fold enrichment of g...
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| Publicado no: | Nat Methods |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4414912/ https://ncbi.nlm.nih.gov/pubmed/25849638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3351 |
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