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Sequencing small genomic targets with high efficiency and extreme accuracy
The detection of minority variants in mixed samples demands methods for enrichment and accurate sequencing of small genomic intervals. We describe an efficient approach based on sequential rounds of hybridization with biotinylated oligonucleotides, enabling more than one-million fold enrichment of g...
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| Publicado en: | Nat Methods |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4414912/ https://ncbi.nlm.nih.gov/pubmed/25849638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3351 |
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