Cooperative loss of RAS feedback regulation drives myeloid leukemognesis

RAS network activation is common in human cancers and, in acute myeloid leukemia (AML), achieved mainly through gain-of-function mutations in KRAS, NRAS, or the FLT3 receptor tyrosine kinase(1). In mice, we show that premalignant myeloid cells harboring a Kras(G12D) allele retain low Ras signaling o...

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I publikationen:Nat Genet
Huvudupphovsmän: Zhao, Zhen, Chen, Chi-Chao, Rillahan, Cory D., Shen, Ronglai, Kitzing, Thomas, McNerney, Megan E., Diaz-Flores, Ernesto, Zuber, Johannes, Shannon, Kevin, Le Beau, Michelle M., Spector, Mona S., Kogan, Scott C., Lowe, Scott W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414804/
https://ncbi.nlm.nih.gov/pubmed/25822087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3251
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