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Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter.

To develop a system for overexpressing genes in the vascular wall, we created transgenic mice using the reporter gene luciferase and the murine preproendothelin-1 promoter. In vitro analysis suggested that the murine 5'-flanking region contained endothelial-specific elements in a 5.9-kb fragment. Fi...

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Published in:J Clin Invest
Main Authors: Harats, D, Kurihara, H, Belloni, P, Oakley, H, Ziober, A, Ackley, D, Cain, G, Kurihara, Y, Lawn, R, Sigal, E
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1995
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC441473/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7883980/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117784
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