Effects of the novel BK (K(Ca)1.1) channel opener GoSlo-SR-5-130 are dependent on the presence of BK(β) subunits

BACKGROUND AND PURPOSE: GoSlo-SR compounds are efficacious BK (K(Ca)1.1) channel openers, but little is known about their mechanism of action or effect on bladder contractility. We examined the effects of two closely related compounds on BK currents and bladder contractions. EXPERIMENTAL APPROACH: A...

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Bibliografiska uppgifter
I publikationen:Br J Pharmacol
Huvudupphovsmän: Large, R J, Kshatri, A, Webb, T I, Roy, S, Akande, A, Bradley, E, Sergeant, G P, Thornbury, K D, McHale, N G, Hollywood, M A
Materialtyp: Artigo
Språk:Inglês
Publicerad: BlackWell Publishing Ltd 2015
Ämnen:
Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409906/
https://ncbi.nlm.nih.gov/pubmed/25598230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13085
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