Effects of the novel BK (K(Ca)1.1) channel opener GoSlo-SR-5-130 are dependent on the presence of BK(β) subunits

BACKGROUND AND PURPOSE: GoSlo-SR compounds are efficacious BK (K(Ca)1.1) channel openers, but little is known about their mechanism of action or effect on bladder contractility. We examined the effects of two closely related compounds on BK currents and bladder contractions. EXPERIMENTAL APPROACH: A...

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Detalles Bibliográficos
Publicado en:Br J Pharmacol
Main Authors: Large, R J, Kshatri, A, Webb, T I, Roy, S, Akande, A, Bradley, E, Sergeant, G P, Thornbury, K D, McHale, N G, Hollywood, M A
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409906/
https://ncbi.nlm.nih.gov/pubmed/25598230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13085
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