Effects of the novel BK (K(Ca)1.1) channel opener GoSlo-SR-5-130 are dependent on the presence of BK(β) subunits

BACKGROUND AND PURPOSE: GoSlo-SR compounds are efficacious BK (K(Ca)1.1) channel openers, but little is known about their mechanism of action or effect on bladder contractility. We examined the effects of two closely related compounds on BK currents and bladder contractions. EXPERIMENTAL APPROACH: A...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Large, R J, Kshatri, A, Webb, T I, Roy, S, Akande, A, Bradley, E, Sergeant, G P, Thornbury, K D, McHale, N G, Hollywood, M A
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2015
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409906/
https://ncbi.nlm.nih.gov/pubmed/25598230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13085
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