Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: Involvement of the S4/S5 linker and the S6 segment

GoSlo-SR-5-6 is a novel large-conductance Ca(2+)-activated K(+) (BK) channel agonist that shifts the activation V(1/2) of these channels in excess of −100 mV when applied at a concentration of 10 μM. Although the structure–activity relationship of this family of molecules has been established, littl...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Webb, Timothy I., Kshatri, Aravind Singh, Large, Roddy J., Akande, Adebola Morayo, Roy, Subhrangsu, Sergeant, Gerard P., McHale, Noel G., Thornbury, Keith D., Hollywood, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4343142/
https://ncbi.nlm.nih.gov/pubmed/25653338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400555112
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