The transcription factor KLF2 restrains CD4(+) T follicular helper cell differentiation

T follicular helper (Tfh) cells are essential for efficient B cell responses, yet the factors that regulate differentiation of this CD4(+) T cell subset are incompletely understood. Here we found that the KLF2 transcription factor serves to restrain Tfh cell generation. Induced KLF2 deficiency in ac...

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Publicado no:Immunity
Main Authors: Lee, June-Yong, Skon, Cara N., Lee, You Jeong, Oh, Soohwan, Taylor, Justin J., Malhotra, Deepali, Jenkins, Marc K., Rosenfeld, M. Geoffrey, Hogquist, Kristin A., Jameson, Stephen C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409658/
https://ncbi.nlm.nih.gov/pubmed/25692701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.01.013
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