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KLF2 deficiency in T cells results in unrestrained cytokine production and bystander chemokine receptor upregulation

The transcription factor KLF2 regulates T cell trafficking by promoting expression of the lipid binding receptor, S1P(1), and the selectin, CD62L. Recently, it was proposed that KLF2 also represses the expression of chemokine receptors. We confirm the upregulation of the chemokine receptor CXCR3 on...

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Detalhes bibliográficos
Main Authors: Weinreich, Michael A., Takada, Kensuke, Skon, Cara, Reiner, Steven L., Jameson, Stephen C., Hogquist, Kristin A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724594/
https://ncbi.nlm.nih.gov/pubmed/19592277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.05.011
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