Interactions Between Nuclear receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice

BACKGROUND & AIMS: Hyperhomocysteinemia is often associated with liver and metabolic diseases. We studied nuclear receptors that mediate oscillatory control of homocysteine homeostasis in mice. METHODS: We studied mice with disruptions in Nr0b2 (called SHP-null mice) Bhmt, or both genes (BHMT-nu...

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發表在:Gastroenterology
Main Authors: Tsuchiya, Hiroyuki, da Costa, Kerry-Ann, Lee, Sangmin, Renga, Barbara, Jaeschke, Hartmut, Yang, Zhihong, Orena, Stephen J., Goedken, Michael J., Zhang, Yuxia, Kong, B, Lebofsky, Margitta, Rudraiah, Swetha, Smalling, Rana, Guo, Grace, Fiorucci, Stefano, Zeisel, Steven H., Wang, Li
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409521/
https://ncbi.nlm.nih.gov/pubmed/25701738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2015.01.045
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