Lead Optimization of Anti-Malarial Propafenone Analogs

Previously reported studies identified analogs of propafenone that had potent antimalarial activity, reduced cardiac ion channel activity, and properties that suggested the potential for clinical development for malaria. Careful examination of the bioavailability, pharmacokinetics, toxicology, and e...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:J Med Chem
Glavni autori: Lowes, David, Pradhan, Anupam, Iyer, Lalitha V., Parman, Toufan, Gow, Jason, Zhu, Fangyi, Furimsky, Anna, Lemoff, Andrew, Guiguemde, W. Armand, Sigal, Martina, Clark, Julie A., Wilson, Emily, Tang, Liang, Connelly, Michele C., DeRisi, Joseph L., Kyle, Dennis E., Mirsalis, Jon, Guy, R. Kiplin
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408918/
https://ncbi.nlm.nih.gov/pubmed/22708838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300286a
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items