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Optimization of Propafenone Analogues as Anti-Malarial Leads
Propafenone, a class Ic antiarrythmic drug, inhibits growth of cultured Plasmodium falciparum. While the drug’s potency is significant, further development of propafenone as an antimalarial would require divorcing the antimalarial and cardiac activities as well as improving the pharmacokinetic profi...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3208124/ https://ncbi.nlm.nih.gov/pubmed/21955244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2005546 |
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