Lead Optimization of Anti-Malarial Propafenone Analogs

Previously reported studies identified analogs of propafenone that had potent antimalarial activity, reduced cardiac ion channel activity, and properties that suggested the potential for clinical development for malaria. Careful examination of the bioavailability, pharmacokinetics, toxicology, and e...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Med Chem
Egile Nagusiak: Lowes, David, Pradhan, Anupam, Iyer, Lalitha V., Parman, Toufan, Gow, Jason, Zhu, Fangyi, Furimsky, Anna, Lemoff, Andrew, Guiguemde, W. Armand, Sigal, Martina, Clark, Julie A., Wilson, Emily, Tang, Liang, Connelly, Michele C., DeRisi, Joseph L., Kyle, Dennis E., Mirsalis, Jon, Guy, R. Kiplin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408918/
https://ncbi.nlm.nih.gov/pubmed/22708838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300286a
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