Loss of Anergic B Cells in Prediabetic and New-Onset Type 1 Diabetic Patients

Although dogma predicts that under normal circumstances, potentially offensive autoreactive cells are silenced by mechanisms of immune tolerance, islet antigen–reactive B lymphocytes are known to play a crucial role in the development of autoimmunity in type 1 diabetes (T1D). Thus, participation of...

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Bibliographische Detailangaben
Veröffentlicht in:Diabetes
Hauptverfasser: Smith, Mia J., Packard, Thomas A., O’Neill, Shannon K., Henry Dunand, Carole J., Huang, Min, Fitzgerald-Miller, Lisa, Stowell, Daniel, Hinman, Rochelle M., Wilson, Patrick C., Gottlieb, Peter A., Cambier, John C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2015
Schlagworte:
Immunology and Transplantation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407867/
https://ncbi.nlm.nih.gov/pubmed/25524915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1798
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