Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles

Although B cells reactive with islet autoantigens are silenced by tolerance mechanisms in healthy individuals, they can become activated and contribute to the development of type 1 diabetes. We previously demonstrated that high-affinity insulin-binding B cells (IBCs) occur exclusively in the anergic...

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Publicat a:Diabetes
Autors principals: Smith, Mia J., Rihanek, Marynette, Wasserfall, Clive, Mathews, Clayton E., Atkinson, Mark A., Gottlieb, Peter A., Cambier, John C.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2018
Matèries:
Immunology and Transplantation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860860/
https://ncbi.nlm.nih.gov/pubmed/29343548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-0937
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