Elevated PTEN expression maintains anergy in human B cells and reveals unexpectedly high repertoire autoreactivity

It has been reported that 2.5%–30% of human peripheral CD27(–) B cells are autoreactive and anergic based on unresponsiveness to antigen receptor (BCR) stimulation and autoreactivity of cloned and expressed BCR. The molecular mechanisms that maintain this unresponsiveness are unknown. Here, we showe...

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Udgivet i:JCI Insight
Main Authors: Smith, Mia J., Ford, B. Rhodes, Rihanek, Marynette, Coleman, Brianne M., Getahun, Andrew, Sarapura, Virginia D., Gottlieb, Peter A., Cambier, John C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413793/
https://ncbi.nlm.nih.gov/pubmed/30728334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.123384
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