Binary and ternary combinations of anti-HIV protease inhibitors: effect on gene expression and functional activity of CYP3A4 and efflux transporters

BACKGROUND: The purpose of this study is to identify the effect of binary and ternary combinations of anti-HIV protease inhibitors (PIs) on the expression of metabolizing enzyme (CYP3A4) and efflux transporters [multidrug resistance-associated protein 2 (MRP2), P-glycoprotein (P-gp) and breast cance...

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Published in:Drug Metabol Drug Interact
Main Authors: Kwatra, Deep, Vadlapudi, Aswani Dutt, Vadlapatla, Ramya Krishna, Khurana, Varun, Pal, Dhananjay, Mitra, Ashim K.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407648/
https://ncbi.nlm.nih.gov/pubmed/24399676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/dmdi-2013-0056
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