TRANSFECTED MDCK CELL LINE WITH ENHANCED EXPRESSION OF CYP3A4 AND P-GLYCOPROTEIN AS A MODEL TO STUDY THEIR ROLE IN DRUG TRANSPORT AND METABOLISM

The aim of this study was to characterize and utilize MDCK cell line expressing CYP3A4 and P-glycoprotein as an in vitro model for evaluating drug-herb and drug-drugs of abuse interactions. MDCK cell line simultaneously expressing P-gp and CYP3A4 (MMC) was developed and characterized by using expres...

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Hlavní autoři: Kwatra, Deep, Budda, Balasubramanyam, Vadlapudi, Aswani Dutt, Vadlapatla, Ramya Krishna, Pal, Dhananjay, Mitra, Ashim K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463753/
https://ncbi.nlm.nih.gov/pubmed/22676443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp200487h
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