Ataxin-2 Regulates RGS8 Translation in a New BAC-SCA2 Transgenic Mouse Model

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant disorder with progressive degeneration of cerebellar Purkinje cells (PCs) and other neurons caused by expansion of a glutamine (Q) tract in the ATXN2 protein. We generated BAC transgenic lines in which the full-length human ATXN2 gene was...

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Publicat a:PLoS Genet
Autors principals: Dansithong, Warunee, Paul, Sharan, Figueroa, Karla P., Rinehart, Marc D., Wiest, Shaina, Pflieger, Lance T., Scoles, Daniel R., Pulst, Stefan M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406435/
https://ncbi.nlm.nih.gov/pubmed/25902068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005182
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