Toward a Biorelevant Structure of Protein Kinase C Bound Modulators: Design, Synthesis, and Evaluation of Labeled Bryostatin Analogs for Analysis with REDOR NMR Spectroscopy

Protein kinase C (PKC) modulators are currently of great importance in preclinical and clinical studies directed at cancer, immunotherapy, HIV eradication, and Alzheimer’s disease. However, the bound conformation of PKC modulators in a membrane environment is not known. Rotational Echo Double Resona...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Loy, Brian A., Lesser, Adam B., Staveness, Daryl, Billingsley, Kelvin L., Cegelski, Lynette, Wender, Paul A.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405261/
https://ncbi.nlm.nih.gov/pubmed/25710634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b00886
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