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Improved Protein Kinase C Affinity through Final Step Diversification of a Simplified Salicylate-Derived Bryostatin Analog Scaffold

[Image: see text] Bryostatin 1, in clinical trials or preclinical development for cancer, Alzheimer’s disease, and a first-of-its-kind strategy for HIV/AIDS eradication, is neither readily available nor optimally suited for clinical use. In preceding work, we disclosed a new class of simplified bryo...

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Detalhes bibliográficos
Publicado no:Org Lett
Main Authors: Wender, Paul A., Staveness, Daryl
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334251/
https://ncbi.nlm.nih.gov/pubmed/25238640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol502492b
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