REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment

[Image: see text] Bryostatin 1 (henceforth bryostatin) is in clinical trials for the treatment of Alzheimer’s disease and for HIV/AIDS eradication. It is also a preclinical lead for cancer immunotherapy and other therapeutic indications. Yet nothing is known about the conformation of bryostatin boun...

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Publicado en:ACS Cent Sci
Autores principales: Yang, Hao, Staveness, Daryl, Ryckbosch, Steven M., Axtman, Alison D., Loy, Brian A., Barnes, Alexander B., Pande, Vijay S., Schaefer, Jacob, Wender, Paul A., Cegelski, Lynette
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2018
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785774/
https://ncbi.nlm.nih.gov/pubmed/29392180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.7b00475
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