Gentamicin differentially alters cellular metabolism of cochlear hair cells as revealed by NAD(P)H fluorescence lifetime imaging

Aminoglycoside antibiotics are implicated as culprits of hearing loss in more than 120,000 individuals annually. Research has shown that the sensory cells, but not supporting cells, of the cochlea are readily damaged and/or lost after use of such antibiotics. High-frequency outer hair cells (OHCs) s...

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Bibliographic Details
Published in:J Biomed Opt
Main Authors: Zholudeva, Lyandysha V., Ward, Kristina G., Nichols, Michael G., Smith, Heather Jensen
Format: Artigo
Language:Inglês
Published: Society of Photo-Optical Instrumentation Engineers 2015
Subjects:
Special Section Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405084/
https://ncbi.nlm.nih.gov/pubmed/25688541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1117/1.JBO.20.5.051032
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