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Gentamicin Rapidly Inhibits Mitochondrial Metabolism in High-Frequency Cochlear Outer Hair Cells

Aminoglycosides (AG), including gentamicin (GM), are the most frequently used antibiotics in the world and are proposed to cause irreversible cochlear damage and hearing loss (HL) in 1/4 of the patients receiving these life-saving drugs. Akin to the results of AG ototoxicity studies, high-frequency,...

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Hlavní autoři: Jensen-Smith, Heather C., Hallworth, Richard, Nichols, Michael G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371036/
https://ncbi.nlm.nih.gov/pubmed/22715386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038471
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