IFNγ producing CD8(+) T cells modified to resist major immune checkpoints induce regression of MHC class I-deficient melanomas

Tumors with reduced expression of MHC class I (MHC-I) molecules may be unrecognized by tumor antigen-specific CD8(+) T cells and thus constitute a challenge for cancer immunotherapy. Here we monitored development of autochthonous melanomas in TiRP mice that develop tumors expressing a known tumor an...

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Publicat a:Oncoimmunology
Autors principals: Buferne, Michel, Chasson, Lionel, Grange, Magali, Mas, Amandine, Arnoux, Fanny, Bertuzzi, Mélanie, Naquet, Philippe, Leserman, Lee, Schmitt-Verhulst, Anne-Marie, Auphan-Anezin, Nathalie
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
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Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404920/
https://ncbi.nlm.nih.gov/pubmed/25949872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/2162402X.2014.974959
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