The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells

The transcription factor NF-κB is central to inflammatory signaling and activation of innate and adaptive immune responses. Activation of the NF-κB pathway is tightly controlled by several negative feedback mechanisms, including A20, an ubiquitin-modifying enzyme encoded by the tnfaip3 gene. Mice wi...

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Detalhes bibliográficos
Main Authors: Giordano, Marilyn, Roncagalli, Romain, Bourdely, Pierre, Chasson, Lionel, Buferne, Michel, Yamasaki, Sho, Beyaert, Rudi, van Loo, Geert, Auphan-Anezin, Nathalie, Schmitt-Verhulst, Anne-Marie, Verdeil, Grégory
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121810/
https://ncbi.nlm.nih.gov/pubmed/25024217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406259111
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